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KMID : 0607520060140020102
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Korean Journal of Psychosomatic Medicine
2006 Volume.14 No. 2 p.102 ~ p.107
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The Relationship of Depressive Symptom and Abstinence Periods in Methamphetamine Dependent Subjects
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Sim Min-Young
Lyoo In-Kyoon
Yoon Su-Jung
Lee Jee-Young
Han Doug-Hyun
Kim Seog-Ju
Bae Su-Jin
Kim Hyung-Jun
Kim Da-Jung
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Abstract
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Objectives : The aim of this study is to evaluate depressive symptom of methamphetamine(MA) dependent subjects and the association between depressive symptom and characteristics of methamphetamine use.
Methods : Forty three MA dependent subjects and 40 healthy comparison subjects were recruited in this study. Characteristics of substance use and depressive symptom using Beck Depression Inventory (BDI) were evaluated.
Results : Average BDI score of methamphetamine group is , which is significantly higher than that of healthy comparison subjects (t=4.04, df=65, p<0.001). Given that 38.9% of MA dependent subjects and 22.6% of healthy comparison subjects are attributed to mild to moderate depressed state and 27.8% of MA dependent subjects and 3.2% of healthy comparison subjects to moderate-severe depressed state, depressive symptom is more frequently observed in MA dependent subjects relative to healthy comparison subjects (p=0.001). On covariating as sex, age, alcohol use and smoking, prevalence of depressive symptom is still higher in MA dependent subjects than healthy comparison subjects (OR=300.7, p=0.012). BDI scores of MA dependent subjects are correlated with abstinence period (r=-0.35, n=36, p=0.042) but not with cumulative dose or duration of use (r=-0.08, n=36, p=0.677 : r=-0.08, n=36, p=0.658).
Conclusion : Depressive symptom was severe and frequently observed in MA dependent subjects. This study suggested that depressive symptom of MA dependent subjects might be not associated with degree of MA use but decreased by persistent abstinence.
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KEYWORD
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Methamphetamine, Depression, Abstinence
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